ACS Publications: High Quality, High Impact

As the most cited journal in Medicinal Chemistry, the Journal of Medicinal Chemistry focuses on original research dealing with chemical-biological relationships, mainly the bond between molecular structure and biological activity.

Editor-in-Chief: Philip S. Portoghese | Editors
Volume: 51, 24 issues

Invitation to Authors: Journal of Medicinal Chemistry Perspective Series

The Perspective series of the Journal of Medicinal Chemistry is designed to provide an enlightened appraisal of a field of research in which experts review the state-of-the-art for a given topic.

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Articles ASAP (As Soon As Publishable)

The Most Recently Published Research

The following list of Articles ASAP is limited to the latest 20 articles. Visit the All Articles ASAP page for the complete listing.

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Web Release Date: May 16, 2008
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Evaluation of Radiolabeled (Hetero)Aromatic Analogues of N-(2-diethylaminoethyl)-4-iodobenzamide for Imaging and Targeted Radionuclide Therapy of Melanoma
Jean-Michel Chezal, Janine Papon, Pierre Labarre, Claire Lartigue, Marie-Josephe Galmier, Caroline Decombat, Olivier Chavignon, Jean Maublant, Jean-Claude Teulade, Jean-Claude Madelmont, and Nicole Moins
Web Release Date: 16-May-2008; (Article) DOI: 10.1021/jm701424g
Abstract   Full:  HTML /  PDF (460K)  Supporting Info 
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Carbonic Anhydrase Inhibitors: Bioreductive Nitro-Containing Sulfonamides with Selectivity for Targeting the Tumor Associated Isoforms IX and XII
Katia D’Ambrosio, Rosa-Maria Vitale, Jean-Michel Dogné, Bernard Masereel, Alessio Innocenti, Andrea Scozzafava, Giuseppina De Simone, and Claudiu T. Supuran
Web Release Date: 16-May-2008; (Article) DOI: 10.1021/jm800121c
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Web Release Date: May 15, 2008
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Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors
Stefania Butini, Giuseppe Campiani, Marianna Borriello, Sandra Gemma, Alessandro Panico, Marco Persico, Bruno Catalanotti, Sindu Ros, Margherita Brindisi, Marianna Agnusdei, Isabella Fiorini, Vito Nacci, Ettore Novellino, Tatyana Belinskaya, Ashima Saxena, and Caterina Fattorusso
Web Release Date: 15-May-2008; (Article) DOI: 10.1021/jm701253t
Abstract   Full:  HTML /  PDF (2206K)  Supporting Info 
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Development and Experimental Validation of a Docking Strategy for the Generation of Kinase-Targeted Libraries
Rafael Gozalbes, Laurence Simon, Nicolas Froloff, Eric Sartori, Claude Monteils, and Romuald Baudelle
Web Release Date: 15-May-2008; (Article) DOI: 10.1021/jm701367r
Abstract   Full:  HTML /  PDF (1526K)  Supporting Info 
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Synthesis and Evaluation of [2-(4-Quinolyloxy)phenyl]methanone Derivatives: Novel Selective Inhibitors of Transforming Growth Factor-β Kinase
Toshiyuki Shimizu, Kaname Kimura, Teruyuki Sakai, Kazuki Kawakami, Tetsuko Miyazaki, Masayoshi Nakouji, Akira Ogawa, Hitomi Ohuchi, and Kiyoshi Shimizu
Web Release Date: 15-May-2008; (Brief Article) DOI: 10.1021/jm701626z
Abstract   Full:  HTML /  PDF (191K)  Supporting Info 
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Histone Deacetylase Inhibitors: From Bench to Clinic
Marielle Paris, Marina Porcelloni, Monica Binaschi, and Daniela Fattori
Web Release Date: 15-May-2008; (Addition/Correction) DOI: 10.1021/jm800398r
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Web Release Date: May 14, 2008
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Synthesis and in Vitro Antiprotozoal Activities of Water-Soluble, Inexpensive 3,7-Bis(dialkylamino)phenoxazin-5-ium Derivatives
Jian-Feng Ge, Chika Arai, Marcel Kaiser, Sergio Wittlin, Reto Brun, and Masataka Ihara
Web Release Date: 14-May-2008; (Brief Article) DOI: 10.1021/jm8003619
Abstract   Full:  HTML /  PDF (112K)  Supporting Info 
Web Release Date: May 13, 2008
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Novel Inhibitors of the v-raf Murine Sarcoma Viral Oncogene Homologue B1 (BRAF) Based on a 2,6-Disubstituted Pyrazine Scaffold
Ion Niculescu-Duvaz, Esteban Roman, Steven R. Whittaker, Frank Friedlos, Ruth Kirk, Ian J. Scanlon, Lawrence C. Davies, Dan Niculescu-Duvaz, Richard Marais, and Caroline J. Springer
Web Release Date: 13-May-2008; (Article) DOI: 10.1021/jm070776b
Abstract   Full:  HTML /  PDF (258K)  Supporting Info 
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Antitumor Agents 260. New Desmosdumotin B Analogues with Improved In Vitro Anticancer Activity
Kyoko Nakagawa-Goto, Kenneth F. Bastow, Tzu-Hsuan Chen, Susan L. Morris-Natschke, and Kuo-Hsiung Lee
Web Release Date: 13-May-2008; (Article) DOI: 10.1021/jm701208v
Abstract   Full:  HTML /  PDF (129K)  Supporting Info 
Web Release Date: May 9, 2008
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Novel Substituted Aminoalkylguanidines as Potential Antihyperglycemic and Food Intake-Reducing Agents
Emanuela Tassoni, Fabio Giannessi, Tiziana Brunetti, Pompeo Pessotto, Michela Renzulli, Massimiliano Travagli, Suvi Rajamäki, Samanta Prati, Secondo Dottori, Federico Corelli, Walter Cabri, Paolo Carminati, and Maurizio Botta
Web Release Date: 09-May-2008; (Letter) DOI: 10.1021/jm8001636
Abstract   Full:  HTML /  PDF (137K)  Supporting Info 
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Development of Novel Antiatherogenic Biaryls: Design, Synthesis, and Reactivity
Mélanie Delomenède, Florence Bedos-Belval, Hubert Duran, Cécile Vindis, Michel Baltas, and Anne Nègre-Salvayre
Web Release Date: 09-May-2008; (Article) DOI: 10.1021/jm7014793
Abstract   Full:  HTML /  PDF (571K)  Supporting Info 
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Modulating the Therapeutic Activity of Nanoparticle Delivered Paclitaxel by Manipulating the Hydrophobicity of Prodrug Conjugates
Steven M. Ansell, Sharon A. Johnstone, Paul G. Tardi, Lily Lo, Sherwin Xie, Yu Shu, Troy O. Harasym, Natashia L. Harasym, Laura Williams, David Bermudes, Barry D. Liboiron, Walid Saad, Robert K. Prud’homme, and Lawrence D. Mayer
Web Release Date: 09-May-2008; (Article) DOI: 10.1021/jm800002y
Abstract   Full:  HTML /  PDF (153K)  Supporting Info 
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Design, Synthesis, and Biological Evaluation of New-Generation Taxoids
Iwao Ojima, Jin Chen, Liang Sun, Christopher P. Borella, Tao Wang, Michael L. Miller, Songnian Lin, Xudong Geng, Larisa Kuznetsova, Chuanxing Qu, David Gallager, Xianrui Zhao, Ilaria Zanardi, Shujun Xia, Susan B. Horwitz, Jon Mallen-St. Clair, Jennifer L. Guerriero, Dafna Bar-Sagi, Jean M. Veith, Paula Pera, and Ralph J. Bernacki
Web Release Date: 09-May-2008; (Article) DOI: 10.1021/jm800086e
Abstract   Full:  HTML /  PDF (723K)  Supporting Info 
Web Release Date: May 8, 2008
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A Prodomain Peptide of Plasmodium falciparum Cysteine Protease (Falcipain-2) Inhibits Malaria Parasite Development
Reshma Korde, Ashima Bhardwaj, Rita Singh, Anand Srivastava, Virander S. Chauhan, Raj K. Bhatnagar, and Pawan Malhotra
Web Release Date: 08-May-2008; (Article) DOI: 10.1021/jm070735f
Abstract   Full:  HTML /  PDF (1200K)  Supporting Info 
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Design and Synthesis of FAJANU: a de Novo C2 Symmetric Cyclopeptide Family
Fayna Garcia-Martin, Luis J. Cruz, Ricard A. Rodriguez-Mias, Ernest Giralt, and Fernando Albericio
Web Release Date: 08-May-2008; (Article) DOI: 10.1021/jm800047b
Abstract   Full:  HTML /  PDF (705K)  Supporting Info 
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Trifluoromethoxyl Substituted Phenylethylene Diamines as High Affinity σ Receptor Ligands with Potent Anti-Cocaine Actions
Trudy A. Smith, Xiaowen Yang, Huifang Wu, Buddy Pouw, Rae R. Matsumoto, and Andrew Coop
Web Release Date: 08-May-2008; (Brief Article) DOI: 10.1021/jm7013666
Abstract   Full:  HTML /  PDF (80K)  Supporting Info 
Web Release Date: May 7, 2008
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Novel 3-Carboxamide-coumarins as Potent and Selective FXIIa Inhibitors
Séverine Robert, Carine Bertolla, Bernard Masereel, Jean-Michel Dogné, and Lionel Pochet
Web Release Date: 07-May-2008; (Letter) DOI: 10.1021/jm8002697
Abstract   Full:  HTML /  PDF (70K)  Supporting Info 
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Discovery of Novel Human Histamine H4 Receptor Ligands by Large-Scale Structure-Based Virtual Screening
Róbert Kiss, Béla Kiss, Árpád Könczöl, Ferenc Szalai, Ivett Jelinek, Valéria László, Béla Noszál, András Falus, and György M. Keserű
Web Release Date: 07-May-2008; (Article) DOI: 10.1021/jm7014777
Abstract   Full:  HTML /  PDF (542K)  Supporting Info 
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Guanidine and 2-Aminoimidazoline Aromatic Derivatives as α2-Adrenoceptor Antagonists. 2. Exploring Alkyl Linkers for New Antidepressants
Fernando Rodriguez, Isabel Rozas, Jorge E. Ortega, Amaia M. Erdozain, J. Javier Meana, and Luis F. Callado
Web Release Date: 07-May-2008; (Article) DOI: 10.1021/jm800026x
Abstract   Full:  HTML /  PDF (213K)  Supporting Info 
Web Release Date: May 6, 2008
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Tuning the DNA Conformational Perturbations Induced by Cytotoxic Platinum−Acridine Bisintercalators: Effect of Metal Cis/Trans Isomerism and DNA Threading Groups
Jayati Roy Choudhury, Rajsekhar Guddneppanavar, Gilda Saluta, Gregory L. Kucera, and Ulrich Bierbach
Web Release Date: 06-May-2008; (Letter) DOI: 10.1021/jm8003569
Abstract   Full:  HTML /  PDF (452K)  Supporting Info 
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