Journal of Proteome Research
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Recent Highlighted Articles
The Plant Phosphoproteome: No Longer a Black Box?
With a phosphopeptide enrichment strategy, researchers identified and pinpointed several known and novel phosphosites on Arabidopsis thaliana proteins. In addition, the investigators used peptide arrays to study the effects of stress on kinase activities. Go to Research Profile
HUPO's Human Proteome Project: The Next Big Thing?
Could this be the human genome project for proteomics? HUPO has just launched a global initiative called the Human Proteome Project in which participants will characterize one protein for every gene in the human genome. Subprojects centered around MS, antibodies, and proteinÐprotein interactions will be pursued. Other projects involve the development of a new, integrative bioinformatics platform and the study of posttranslational modifications. Go to article.
- Related Content
- June News Stories
Crop Proteomics and Its Application to Biotechnology
In this month's guest editorial, JPR Associate Editor Setsuko Komatsu of the National Institute of Crop Science and University of Tsukuba (both in Japan) discusses the importance of taking a proteomic approach to agricultural research. In particular, protein arrays could prove to be valuable tools for such investigations, she says, although they still must be optimized. Go to June editorial
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- June News Stories
U.S. HUPO Fourth Annual Conference Meeting News
At the U.S. HUPO conference in March, researchers presented the results of a competition called CAMSI in which various peptide identification algorithms were compared. The bottom line? Researchers should be careful when estimating false discovery rates with algorithms that take protein-level information into account. In addition, researchers presented data on imaging MS and performing analyses on fixed tissues.
Location Proteomics Analysis of Human Protein Atlas Images
The Human Protein Atlas includes thousands of images, but few scientists have the time to sit down and manually sort through them. So, researchers have developed an automated method to determine the subcellular locations of proteins in these images. Go to Research Profile
Advances in the Analysis of Protein Phosphorylation
In this review, Alberto Paradela and Juan Pablo Albar of the Spanish National Research Council (known as CSIC) discuss popular strategies, including enrichment techniques and ways to identify phosphosites, for the analysis of protein phosphorylation.
HUPO's Human Proteome Project: The Next Big Thing?
Could this be the human genome project for proteomics? HUPO has just launched a global initiative called the Human Proteome Project in which participants will characterize one protein for every gene in the human genome. Subprojects centered around MS, antibodies, and proteinÐprotein interactions will be pursued. Other projects involve the development of a new, integrative bioinformatics platform and the study of posttranslational modifications. Read more details in this online-first article.
- Related Content
- May News Stories
Move Over Proteomics, Here Comes Glycomics
In this month's guest editorial, Sudhir Srivastava of the U.S. National Cancer Institute (NCI) explains why research on sugars is important for cancer research. In addition, he describes a new NCI initiative called the Alliance of Glycobiologists for Detection of Cancer and Cancer Risk, in which scientists investigate the use of carbohydrates as biomarkers. Go to May editorial
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- May News Stories
Using Aptamers to Identify Cancer Cell Biomarkers
Aptamers are single-stranded DNAs or RNAs that, like antibodies, bind specifically to target molecules, such as proteins. Researchers have started to use aptamers to discover possible biomarkers on the surfaces of cancer cells. Go to Research Profile
Protein-Complex Characterization Goes Tagless
Scientists usually perform affinity pull-down experiments to isolate protein complexes, but this type of approach is not possible when an organism that is genetically intractable. Also, a tag may alter the native protein's activities. Therefore, researchers have developed a tagless method. Go to Research Profile
Highlights Archive
Are you wondering which articles we've highlighted in the past? Get caught up on previously featured articles at our Highlights Archive.
The Journal of Proteome Research integrates the fields of chemistry, mathematics, applied physics, biology, and medicine in order to better understand the function of proteins in biological systems.
Research Highlights
The Effect of Ozone on Rice Seedlings
Ozone can have deleterious effects on plants. To determine the early molecular events caused by ground-level ozone pollution, researchers conducted transcriptomics, proteomics, and metabolomics experiments on rice. The levels of several transcripts, proteins, and metabolites were differentially regulated when rice were exposed to a high concentration of ozone. Go to Research Profile
- Related Content
- Integrated Transcriptomics, Proteomics, and Metabolomics Analyses to Survey Ozone Responses in the Leaves of Rice Seedling
- Survey of Differentially Expressed Proteins and Genes in Jasmonic Acid Treated Rice Seedling Shoot and Root at the Proteomics and Transcriptomics Levels
- July News Stories
Is Your Protein on the Hit Parade?
Amongst themselves, proteomics researchers have complained of identifying the same proteins over and over again. Now, investigators at several institutions in the Czech Republic and the University of California Berkeley finally have proven that the anecdote is true and have backed it up with evidence.
First Draft of the Human Ductal Salivary Proteome
A large consortium of researchers funded by the National Institute of Dental and Craniofacial Research have performed several different methods to determine the protein composition of salivary secretions. The initial characterization of this proteome has just been published in JPR.
- Related Content
- First Draft of the Human Ductal Salivary Proteome
- The Proteomes of Human Parotid and Submandibular/Sublingual Gland Salivas Collected as the Ductal Secretions
- Characterization of the Human Salivary Proteome by Capillary Isoelectric Focusing/Nanoreversed-Phase Liquid Chromatography Coupled with ESI-Tandem MS
- July News Stories
GlycoScience Ireland Initiative
In this month's guest editorial, Pauline M. Rudd, Gavin Davey, Lokesh Joshi, and Maurice N. Treacy of various institutions in Ireland discuss a new research network called GlycoScience Ireland. The goal of this initiative is to encourage interdisciplinary collaborations for the development of new approaches to scientific challenges. Go to July editorial
- Related Content
- July News Stories
Enrichment of Plasma Membrane Proteins from Pluripotent Cells
Sometimes, human embryonic stem cells (hESCs) become cancerous. With the ultimate goal of differentiating normal hESCs from those that are cancerous, researchers have developed a new method for the enrichment of plasma membrane proteins from these cell types for further study. Go to Research Profile
- Related Content
- Plasma Membrane Proteomics of Human Embryonic Stem Cells and Human Embryonal Carcinoma Cells
- Identification of Mouse Embryonic Stem Cell-Associated Proteins
- Enrichment of Integral Membrane Proteins for Proteomic Analysis Using Liquid Chromatography-Tandem Mass Spectrometry
- July News Stories
Highlights Archive
Are you wondering which research papers we've showcased in the past? Or perhaps you want to look at a recently highlighted News article. Get caught up on previously featured articles and research papers at our Highlights Archive.
Podcast Archive
From time to time, we produce podcasts about interesting papers or special issues. Find all of the previous JPR podcasts in one place—visit our Podcast Archive.
Articles ASAP (As Soon As Publishable)
The Most Recently Published Research
The following list of Articles ASAP is limited to the latest 20 articles. Visit the All Articles ASAP page for the complete listing.
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