Chemical Research in Toxicology: Latest Articles (ACS Publications)

A 13-Oxo-9,10-epoxytridecenoate Phospholipid Analogue of the Genotoxic 4,5-Epoxy-2E-decenal: Detection in Vivo, Chemical Synthesis, and Adduction with DNA

Clementina Mesaros et al — Thu, 04 Feb 2010 18:28:26 GMT

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Proteins Modified by the Lipid Peroxidation Aldehyde 9,12-Dioxo-10(E)-dodecenoic Acid in MCF7 Breast Cancer Cells

Peter G. Slade et al — Thu, 04 Feb 2010 14:27:11 GMT

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New Biomarkers for Monitoring the Levels of Isothiocyanates in Humans

Anoop Kumar et al — Thu, 04 Feb 2010 13:34:38 GMT

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Reactive Oxygen Species-Activated Akt/ASK1/p38 Signaling Pathway in Nickel Compound-Induced Apoptosis in BEAS 2B Cells

Jingju Pan et al — Fri, 29 Jan 2010 18:23:33 GMT

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Polymerase Incorporation and Miscoding Properties of 5-Chlorouracil

Cherine H. Kim et al — Thu, 28 Jan 2010 12:06:39 GMT

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Novel Enzymatic Function of DNA Polymerase ν in Translesion DNA Synthesis Past Major Groove DNA−Peptide and DNA−DNA Cross-Links

Kinrin Yamanaka et al — Tue, 26 Jan 2010 21:23:19 GMT

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Complex Gene−Chemical Interactions: Hepatic Uroporphyria As a Paradigm

Andrew G. Smith et al — Mon, 25 Jan 2010 14:51:24 GMT

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Per- and Polyfluoro Toxicity (LC50 Inhalation) Study in Rat and Mouse Using QSAR Modeling

Barun Bhhatarai et al — Fri, 22 Jan 2010 16:39:57 GMT

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Cytochrome P450-Mediated Epoxidation of 2-Aminothiazole-Based AKT Inhibitors: Identification of Novel GSH Adducts and Reduction of Metabolic Activation through Structural Changes Guided by in Silico and in Vitro Screening

Raju Subramanian et al — Fri, 22 Jan 2010 15:30:41 GMT

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Genotoxicity of Soluble and Particulate Cadmium Compounds: Impact on Oxidative DNA Damage and Nucleotide Excision Repair

Tanja Schwerdtle et al — Thu, 21 Jan 2010 16:10:40 GMT

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Glucuronidation, a New Metabolic Pathway for Pyrrolizidine Alkaloids

Yu-Qi He et al — Thu, 21 Jan 2010 16:10:30 GMT

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Reactivity of Zn-, Cd-, and Apo-Metallothionein with Nitric Oxide Compounds: In Vitro and Cellular Comparison

Jianyu Zhu et al — Tue, 19 Jan 2010 18:00:36 GMT

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Does Vitreous Silica Contradict the Toxicity of the Crystalline Silica Paradigm?

Mara Ghiazza et al — Tue, 19 Jan 2010 17:03:41 GMT

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Impact of the Pectenotoxin C-43 Oxidation Degree on Its Cytotoxic Effect on Rat Hepatocytes

Begoña Espiña et al — Tue, 19 Jan 2010 17:03:10 GMT

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A New General Pathway for Synthesis of Reference Compounds of N-Terminal Valine−Isocyanate Adducts

Ronnie Davies et al — Tue, 19 Jan 2010 13:29:52 GMT

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Characterization of the Intestinal Absorption of Arsenate, Monomethylarsonic Acid, and Dimethylarsinic Acid Using the Caco-2 Cell Line

Marta Calatayud et al — Fri, 15 Jan 2010 19:01:00 GMT

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Toxicology of Autoimmune Diseases

K. Michael Pollard et al — Fri, 15 Jan 2010 18:56:36 GMT

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High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry for the Detection and Quantitation of Pyrrolizidine Alkaloid-Derived DNA Adducts in Vitro and in Vivo

Peter P. Fu et al — Fri, 15 Jan 2010 16:54:19 GMT

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In Silico Studies of Polyaromatic Hydrocarbon Inhibitors of Cytochrome P450 Enzymes 1A1, 1A2, 2A6, and 2B1

Jayalakshmi Sridhar et al — Fri, 15 Jan 2010 16:53:30 GMT

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Zinc Finger Transcription Factor Zn3-Sp1 Reactions with Cd2+

Rajendra Kothinti et al — Thu, 14 Jan 2010 16:14:42 GMT

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Mass Spectrometric Evidence for the Existence of Distinct Modifications of Different Proteins by 2(E),4(E)-Decadienal

Xiaochun Zhu et al — Wed, 13 Jan 2010 13:00:24 GMT

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2,3,7,8-Tetrachlorodibenzo-p-dioxin Upregulates FoxQ1b in Zebrafish Jaw Primordium

Antonio Planchart et al — Thu, 07 Jan 2010 16:26:49 GMT

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DNA Modifications by the ω-3 Lipid Peroxidation-Derived Mutagen 4-Oxo-2-hexenal in Vitro and Their Analysis in Mouse and Human DNA

Kazuaki Kawai et al — Thu, 07 Jan 2010 16:25:49 GMT

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2,6-Dithiopurine Blocks Toxicity and Mutagenesis in Human Skin Cells Exposed to Sulfur Mustard Analogues, 2-Chloroethyl Ethyl Sulfide and 2-Chloroethyl Methyl Sulfide

K. Leslie Powell et al — Tue, 05 Jan 2010 18:09:17 GMT

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Detoxication of Sulfur Half-Mustards by Nucleophilic Scavengers: Robust Activity of Thiopurines

Jinyun Liu et al — Tue, 05 Jan 2010 18:08:45 GMT

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Myeloperoxidase: An Oxidative Pathway for Generating Dysfunctional High-Density Lipoprotein

Baohai Shao et al — Thu, 31 Dec 2009 16:55:38 GMT

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Arsenic-Induced Carcinogenesis—Oxidative Stress as a Possible Mode of Action and Future Research Needs for More Biologically Based Risk Assessment

Kirk T. Kitchin et al — Mon, 28 Dec 2009 12:38:22 GMT

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Chronic Exposure to Zinc Chromate Induces Centrosome Amplification and Spindle Assembly Checkpoint Bypass in Human Lung Fibroblasts

Amie L. Holmes et al — Wed, 23 Dec 2009 22:06:31 GMT

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Influence of Substrate Complexity on the Diastereoselective Formation of Spiroiminodihydantoin and Guanidinohydantoin from Chromate Oxidation

Julia N. Gremaud et al — Wed, 16 Dec 2009 13:14:15 GMT

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Suppression of p53 and p21CIP1/WAF1 Reduces Arsenite-Induced Aneuploidy

Ana María Salazar et al — Thu, 10 Dec 2009 19:45:43 GMT

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Comparative Genotoxicity and Cytotoxicity of Four Hexavalent Chromium Compounds in Human Bronchial Cells

Sandra S. Wise et al — Thu, 10 Dec 2009 19:43:45 GMT

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Chromium(VI) Stimulates Fyn to Initiate Innate Immune Gene Induction in Human Airway Epithelial Cells

Antonia A. Nemec et al — Tue, 08 Dec 2009 20:14:50 GMT

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Photocytotoxic trans-Diam(m)ine Platinum(IV) Diazido Complexes More Potent than Their cis Isomers

Nicola J. Farrer et al — Tue, 08 Dec 2009 12:59:54 GMT

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Risks of Copper and Iron Toxicity during Aging in Humans

George J. Brewer — Mon, 07 Dec 2009 17:25:51 GMT

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The Cu(II)/Aβ/Human Serum Albumin Model of Control Mechanism for Copper-Related Amyloid Neurotoxicity

Małgorzata Rózga et al — Tue, 01 Dec 2009 19:53:56 GMT

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Variation of Keratin 7 Expression and Other Phenotypic Characteristics of Independent Isolates of Cadmium Transformed Human Urothelial Cells (UROtsa)

Seema Somji et al — Thu, 19 Nov 2009 12:40:48 GMT

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A Direct Determination of the Dissociation Constant for the Cu(II) Complex of Amyloid β 1−40 Peptide

Małgorzata Rózga et al — Fri, 13 Nov 2009 16:57:52 GMT

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Mechanism of DNA−Protein Cross-Linking by Chromium

Andrea Macfie et al — Fri, 30 Oct 2009 14:36:34 GMT

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Metal Allergy—A Review on Exposures, Penetration, Genetics, Prevalence, and Clinical Implications

Jacob P. Thyssen et al — Fri, 16 Oct 2009 11:35:06 GMT

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Depleted Uranium Induces Neoplastic Transformation in Human Lung Epithelial Cells

Hong Xie et al — Thu, 10 Dec 2009 19:43:42 GMT

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A New Decade

Lawrence J. Marnett — Mon, 18 Jan 2010 05:00:00 GMT

Chemical Research in Toxicology, Volume 23, Issue 1, Page 1, January 18, 2010.

In This Issue

Mon, 18 Jan 2010 05:00:00 GMT

Chemical Research in Toxicology, Volume 23, Issue 1, Page 2-3, January 18, 2010.

Spotlight

Mon, 18 Jan 2010 05:00:00 GMT

Chemical Research in Toxicology, Volume 23, Issue 1, Page 4-5, January 18, 2010.

Anthracycline Degradation in Cardiomyocytes: A Journey to Oxidative Survival

Pierantonio Menna et al — Mon, 18 Jan 2010 05:24:55 GMT

Chemical Research in Toxicology, Volume 23, Issue 1, Page 6-10, January 18, 2010.

Efficient Formation of the Tandem Thymine Glycol/8-Oxo-7,8-dihydroguanine Lesion in Isolated DNA and the Mutagenic and Cytotoxic Properties of the Tandem Lesions in Escherichia coli Cells

Bifeng Yuan et al — Mon, 18 Jan 2010 05:28:06 GMT

Chemical Research in Toxicology, Volume 23, Issue 1, Page 11-19, January 18, 2010.

A Large-Scale Quantitative Proteomic Approach To Identifying Sulfur Mustard-Induced Protein Phosphorylation Cascades

Patrick A. Everley et al — Mon, 18 Jan 2010 05:25:40 GMT

Chemical Research in Toxicology, Volume 23, Issue 1, Page 20-25, January 18, 2010.

In Silico Pharmacophore Model for Tabun-Inhibited Acetylcholinesterase Reactivators: A Study of Their Stereoelectronic Properties

Apurba K. Bhattacharjee et al — Mon, 18 Jan 2010 05:04:17 GMT

Chemical Research in Toxicology, Volume 23, Issue 1, Page 26-36, January 18, 2010.

Site-Specific Protein Adducts of 4-Hydroxy-2(E)-Nonenal in Human THP-1 Monocytic Cells: Protein Carbonylation Is Diminished by Ascorbic Acid

Juan Chavez et al — Mon, 18 Jan 2010 05:24:02 GMT

Chemical Research in Toxicology, Volume 23, Issue 1, Page 37-47, January 18, 2010.

Generation of 2′-Deoxyadenosine N6-Aminyl Radicals from the Photolysis of Phenylhydrazone Derivatives

Vandana Kuttappan-Nair et al — Mon, 18 Jan 2010 05:16:52 GMT

Chemical Research in Toxicology, Volume 23, Issue 1, Page 48-54, January 18, 2010.

Passive Dosing for Producing Defined and Constant Exposure of Hydrophobic Organic Compounds during in Vitro Toxicity Tests

Kilian E. C. Smith et al — Mon, 18 Jan 2010 05:29:05 GMT

Chemical Research in Toxicology, Volume 23, Issue 1, Page 55-65, January 18, 2010.

Analysis of 23 Polycyclic Aromatic Hydrocarbons in Smokeless Tobacco by Gas Chromatography−Mass Spectrometry

Irina Stepanov et al — Mon, 18 Jan 2010 05:02:35 GMT

Chemical Research in Toxicology, Volume 23, Issue 1, Page 66-73, January 18, 2010.

Quantification of N2-Carboxymethyl-2′-deoxyguanosine in Calf Thymus DNA and Cultured Human Kidney Epithelial Cells by Capillary High-Performance Liquid Chromatography−Tandem Mass Spectrometry Coupled with Stable Isotope Dilution Method

Hongxia Wang et al — Mon, 18 Jan 2010 05:28:46 GMT

Chemical Research in Toxicology, Volume 23, Issue 1, Page 74-81, January 18, 2010.

Probing the Dynamic Effect of Cys-CdTe Quantum Dots toward Cancer Cells in Vitro

Chunhui Wu et al — Mon, 18 Jan 2010 05:18:12 GMT

Chemical Research in Toxicology, Volume 23, Issue 1, Page 82-88, January 18, 2010.

Structures of Covalent Adducts between DNA and Ochratoxin A: A New Factor in Debate about Genotoxicity and Human Risk Assessment

Peter G. Mantle et al — Mon, 18 Jan 2010 05:02:08 GMT

Chemical Research in Toxicology, Volume 23, Issue 1, Page 89-98, January 18, 2010.

Characterization of DNA Damage Induced by a Natural Product Antitumor Antibiotic Leinamycin in Human Cancer Cells

Velliyur Viswesh et al — Mon, 18 Jan 2010 05:29:50 GMT

Chemical Research in Toxicology, Volume 23, Issue 1, Page 99-107, January 18, 2010.

Low-Concentration Ozone Reacts with Plasmalogen Glycerophosphoethanolamine Lipids in Lung Surfactant

Kelly M. Wynalda et al — Mon, 18 Jan 2010 05:26:12 GMT

Chemical Research in Toxicology, Volume 23, Issue 1, Page 108-117, January 18, 2010.

Exocyclic Deoxyadenosine Adducts of 1,2,3,4-Diepoxybutane: Synthesis, Structural Elucidation, and Mechanistic Studies

Uthpala Seneviratne et al — Mon, 18 Jan 2010 05:26:43 GMT

Chemical Research in Toxicology, Volume 23, Issue 1, Page 118-133, January 18, 2010.

Chemical Structure Determination of DNA Bases Modified by Active Metabolites of Lucidin-3-O-primeveroside

Yuji Ishii et al — Mon, 18 Jan 2010 05:30:45 GMT

Chemical Research in Toxicology, Volume 23, Issue 1, Page 134-141, January 18, 2010.

Identification of Furan Metabolites Derived from Cysteine−cis-2-Butene-1,4-dial−Lysine Cross-Links

Ding Lu et al — Mon, 18 Jan 2010 05:15:12 GMT

Chemical Research in Toxicology, Volume 23, Issue 1, Page 142-151, January 18, 2010.

Approach for in Vivo Protein Binding of 5-n-Butyl-pyrazolo[1,5-a]pyrimidine Bioactivated in Chimeric Mice with Humanized Liver by Two-Dimensional Electrophoresis with Accelerator Mass Spectrometry

Hiroshi Yamazaki et al — Mon, 18 Jan 2010 05:21:00 GMT

Chemical Research in Toxicology, Volume 23, Issue 1, Page 152-158, January 18, 2010.

Bioactivation of Lamotrigine in Vivo in Rat and in Vitro in Human Liver Microsomes, Hepatocytes, and Epidermal Keratinocytes: Characterization of Thioether Conjugates by Liquid Chromatography/Mass Spectrometry and High Field Nuclear Magnetic Resonance Spectroscopy

Hao Chen et al — Mon, 18 Jan 2010 05:24:36 GMT

Chemical Research in Toxicology, Volume 23, Issue 1, Page 159-170, January 18, 2010.

Cheminformatics Analysis of Assertions Mined from Literature That Describe Drug-Induced Liver Injury in Different Species

Denis Fourches et al — Mon, 18 Jan 2010 05:25:19 GMT

Chemical Research in Toxicology, Volume 23, Issue 1, Page 171-183, January 18, 2010.

Metabolic and Chemical Origins of Cross-Reactive Immunological Reactions to Arylamine Benzenesulfonamides: T-Cell Responses to Hydroxylamine and Nitroso Derivatives

J. Luis Castrejon et al — Mon, 18 Jan 2010 05:23:23 GMT

Chemical Research in Toxicology, Volume 23, Issue 1, Page 184-192, January 18, 2010.

Modulation of the Mitochondrial Cytochrome bc1 Complex Activity by Chromanols and Related Compounds

Andrea Müllebner et al — Mon, 18 Jan 2010 05:21:44 GMT

Chemical Research in Toxicology, Volume 23, Issue 1, Page 193-202, January 18, 2010.

Specific Adducts Formed through a Radical Reaction between Peptides and Contact Allergenic Hydroperoxides

Theres Redeby et al — Mon, 18 Jan 2010 05:01:41 GMT

Chemical Research in Toxicology, Volume 23, Issue 1, Page 203-210, January 18, 2010.

Synthesis and in Vitro Cytotoxicity Profile of the R-Enantiomer of 3,4-Dihydroxymethamphetamine (R-(−)-HHMA): Comparison with Related Catecholamines

Anne Felim et al — Mon, 18 Jan 2010 05:15:45 GMT

Chemical Research in Toxicology, Volume 23, Issue 1, Page 211-219, January 18, 2010.

Determination of Spatial Distribution of Melamine−Cyanuric Acid Crystals in Rat Kidney Tissue by Histology and Imaging Matrix-Assisted Laser Desorption/Ionization Quadrupole Time-of-Flight Mass Spectrometry

Chae-Wook Kim et al — Mon, 18 Jan 2010 05:16:15 GMT

Chemical Research in Toxicology, Volume 23, Issue 1, Page 220-227, January 18, 2010.

Experimental Reactivity Parameters for Toxicity Modeling: Application to the Acute Aquatic Toxicity of SN2 Electrophiles to Tetrahymena pyriformis

David W. Roberts et al — Mon, 18 Jan 2010 05:16:31 GMT

Chemical Research in Toxicology, Volume 23, Issue 1, Page 228-234, January 18, 2010.

DNA Interstrand Cross-Linking Activity of (1-Chloroethenyl)oxirane, a Metabolite of β-chloroprene

Brian A. Wadugu et al — Mon, 18 Jan 2010 05:03:28 GMT

Chemical Research in Toxicology, Volume 23, Issue 1, Page 235-239, January 18, 2010.

Characterization of Scavengers of γ-Ketoaldehydes That Do Not Inhibit Prostaglandin Biosynthesis

Irene Zagol-Ikapitte et al — Mon, 18 Jan 2010 05:00:54 GMT

Chemical Research in Toxicology, Volume 23, Issue 1, Page 240-250, January 18, 2010.

New Urinary Metabolites Formed from Ring-Oxidized Metabolic Intermediates of Styrene

Igor Linhart et al — Mon, 18 Jan 2010 05:27:46 GMT

Chemical Research in Toxicology, Volume 23, Issue 1, Page 251-257, January 18, 2010.

Radiation Chemical Studies of Methionine in Aqueous Solution: Understanding the Role of Molecular Oxygen

Sebastián Barata-Vallejo et al — Mon, 18 Jan 2010 05:22:42 GMT

Chemical Research in Toxicology, Volume 23, Issue 1, Page 258-263, January 18, 2010.

Abstracts, American Chemical Society Division of Chemical Toxicology, 238th National Meeting and Exposition, Washington, DC, August 16−20, 2009

Kaushik Mitra et al — Mon, 18 Jan 2010 05:27:31 GMT

Chemical Research in Toxicology, Volume 23, Issue 1, Page 264-290, January 18, 2010.