SMALL-MOLECULE DIFFERENTIATION A branching DOS pathway leads to efficient syntheses of complex and skeletally diverse small molecules.30 Beginning in lower middle, alde-hydes are converted to unsaturated alcohols, and then to unsaturated, cyclic boronic esters. The latter species can be converted to a wide variety of products having skeletal diversity. The overall process is analogous to the differentiation of early lineage cells to middle and then late lineage cells. Differentiation in the DOS
pathway, in this particular example, is dictated by the selection of reagents ("reagent-encoded"). An alternative process ("substrate-encoded") is discussed in the text.
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