March 3, 2003
Volume 81, Number 9
CENEAR 81 9 p. 59
ISSN 0009-2347

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DIVERSITY-ORIENTED SYNTHESIS Structures of representative small molecules synthesized using DOS principles and prepared as 5-mM stock solutions using the one bead/one stock solution technology platform: secramine³¹ (specific modulator of protein trafficking out of the Golgi apparatus; secramine is one member of a total of 2,800 small molecules prepared using DOS); calmoduphilin³² (K_d = 0.12 uM/calmodulin; one member of 29,400 total); haptamide³³ (inhibitor of Hap3p-mediated transcription; one member of 4,320 total); uretupamine³⁴ (binds to Ure2p and activates Nil1p-mediated transcription; one member of 32,000 total)²²; tetracycle (one member of 2,500 total); tubacin³⁵ (tubulin deacetylase inhibitor; one member of 7,200 deacetylase-biased dioxanes); macrolide³⁶ (one member of 36 total); macrocyclic biaryl³⁷ (affects cardiovascular system during zebrafish development; enantiomer has no activity; one member of 1,412 total).

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