October 27, 2003
Volume 81, Number 43
CENEAR 81 43 pp. 45-56
ISSN 0009-2347

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IRREVERSIBLE In a demonstration of pseudodynamic combinatorial chemistry, Kazlauskas, Gleason, and coworkers showed that an irreversible hydrolysis reaction could be used to select for aryl sulfonamide dipeptides that bound most strongly to--and were thus potentially the best inhibitors (Ibest) of--a carbonic anhydrase target. R = variable functional group, X = activating group.