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Article

The Gif Paradox

Pericles Stavropoulos,* Remle Çelenligil-Çetin, and Amy E. Tapper

Department of Chemistry, Boston University, Boston, Massachusetts 02215

Acc. Chem. Res., 2001, 34 (9), pp 745–752

DOI: 10.1021/ar000100+

Publication Date (Web): July 17, 2001

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

Pericles Stavropoulos earned a B.S. degree in chemistry from the University of Athens, Greece, and a Ph.D. degree from Imperial College, London (with Geoffrey Wilkinson). Following postdoctoral appointments at the University of Strasbourg (with John A. Osborn) and Harvard University (with Richard H. Holm), he joined the faculty of Boston University.

Remle Çelenligil-Çetin received a B.S. degree in chemistry from Bogaziçi University, Istanbul, Turkey. She is currently a graduate student at Boston University engaged in the development of iron oxygenation reagents.

Amy E. Tapper received a B.S. degree in chemistry from Boston College. She is currently completing her Ph.D. degree at Boston University on metal-dependent oxygenations of alkanes and amyloid peptides related to Alzheimer's disease.

Abstract

This Account summarizes research work on the structural aspects and functional features encountered in all major branches of the Gif family of hydrocarbon-oxidizing reagents. Despite assertions by the inventor of Gif chemistry, D. H. R. Barton, to the effect that nonradical pathways could better explain the behavior of Gif systems, detailed experimental investigations provide compelling evidence to support the preponderance of oxygen- and carbon-centered radical chemistry.

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