Web Release Date: June 28,
Hydrogels Formed by Multiple Peptide Ligation Reactions To Fasten Corneal Transplants
and
Departments of Biomedical Engineering and Chemistry, Metcalf Center for Science and Engineering, Boston University, Boston, Massachusetts 02215, and Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710
Received March 7, 2006
Revised May 31, 2006
Abstract:
A stable cross-linked hydrogel was formed under mild aqueous conditions using pseudoproline peptide ligation chemistry. A cysteine-terminated lysine dendron containing four cysteines and a PEG macromolecule modified with terminal ester aldehydes were prepared. Upon mixing, the two macromers gave a stable hydrogel. This hydrogel along with sutures was used to successfully secure a corneal transplant in vitro.
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