Web Release Date: July 25,
Moving Known Libraries to an Addressable Array: A Site-Selective Hetero-Michael Reaction
Department of Chemistry, Campus Box 1134, Washington University, St. Louis, Missouri 63130, and CombiMatrix Corporation, 6500 Harbor Heights Parkway, Suite 301, Mukilteo, Washington 98275
Received January 21, 2008
Revised Manuscript Received June 6, 2008
Abstract:
A two-step, Michael reaction-based strategy for site-selectively placing molecules by unique electrodes in an addressable microelectrode array has been developed. The strategy is compatible with the use of polypeptide nucleophiles and works with microelectrode arrays having either 1024 electrodes/cm2 or 12 544 electrodes/cm2. The chemistry should allow for the transfer of existing molecular libraries to microelectrode array devices for analysis.
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