Prev. Article Next Article Table of Contents

Article

Solubility of Antibiotics in Different Solvents. 1. Hydrochloride Forms of Tetracycline, Moxifloxacin, and Ciprofloxacin

Fátima Varanda,^† Maria J. Pratas de Melo,^† Ana I. Caço,^† Ralf Dohrn,^‡ Foteini A. Makrydaki,^‡^§ Epaminondas Voutsas,^§ Dimitrios Tassios,^§ and Isabel M. Marrucho*^†

Department of Chemistry, University of Aveiro, CICECO, 3810-293.15 Aveiro, Portugal, Thermophysical Properties, Bayer Technology Services GmbH, B310, 51368 Leverkusen, Germany, and Department of Chemical Engineering, National Technical University of Athens, TTPL, Zografou Campus, GR-15780, Athens, Greece

Ind. Eng. Chem. Res., 2006, 45 (18), pp 6368–6374

DOI: 10.1021/ie060055v

Publication Date (Web): July 29, 2006

†

Department of Chemistry, University of Aveiro.

‡

Thermophysical Properties, Bayer Technology Services GmbH.

Department of Chemical Engineering, National Technical University of Athens, TTPL.

To whom correspondence should be addressed. E-mail address: imarrucho@dq.ua.pt.

Abstract

The solubilities of tetracycline hydrochloride, moxifloxacin hydrochloride, and ciprofloxacin hydrochloride were measured in several solvents, such as water, ethanol, 2-propanol, and acetone, in the temperature range of 293.15−323.15 K for ciprofloxacin.HCl and moxifloxacin.HCl and 288.15−310.15 K for tetracycline. All the antibiotics have the same solubility order; that is, they are more soluble in water than in ethanol, and more soluble in ethanol than in 2-propanol and acetone. The solubility in water is 3 orders of magnitude higher than that in acetone. The modeling of the experimental solid−liquid equilibria (SLE) data, using the NRTL and UNIQUAC models, proves that these models can correlate the solubility of studied antibiotics satisfactorily in the temperature range for which experimental data are available, with the UNIQUAC model generally being slightly superior to the NRTL model, when only two adjustable parameters are used for each binary system.