Web Release Date: June 2,
A Chondroitin Sulfate Small Molecule that Stimulates Neuronal Growth
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125
Received March 19, 2004
Abstract:
Chondroitin sulfate glycosaminoglycans are sulfated polysaccharides involved in cell division, neuronal development, and spinal cord injury. Here, we report the synthesis and identification of a chondroitin sulfate tetrasaccharide that stimulates the growth and differentiation of neurons. These studies represent the first, direct investigations into the structure-activity relationships of chondroitin sulfate using homogeneous synthetic molecules and define a tetrasaccharide as a minimal motif required for activity.
Download the full text: PDF | HTML
