Cationic Carbon Nanotubes Bind to CpG Oligodeoxynucleotides and Enhance Their Immunostimulatory Properties

J. Am. Chem. Soc., 127 (1), 58 -59, 2005. 10.1021/ja044293y S0002-7863(04)04293-3
Web Release Date: December 16, 2004

Cationic Carbon Nanotubes Bind to CpG Oligodeoxynucleotides and Enhance Their Immunostimulatory Properties

Alberto Bianco,* Johan Hoebeke, Sylvie Godefroy, Olivier Chaloin, Davide Pantarotto, Jean-Paul Briand, Sylviane Muller, Maurizio Prato,* and Charalambos D. Partidos*

Institut de Biologie Moléculaire et Cellulaire, UPR9021 CNRS, Immunologie et Chimie Thérapeutiques, 67084 Strasbourg, France, and Dipartimento di Scienze Farmaceutiche, Università di Trieste, 34127 Trieste, Italy

A.Bianco@ibmc.u-strasbg.fr; H.Partidos@ibmc.u-strasbg.fr

Received September 20, 2004

Abstract:

Functionalized cationic carbon nanotubes are able to form a stable complex with CpG ODN based on charge interaction and to increase the immunostimulatory activity of CpG motifs.

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