Web Release Date: January 15,
A Role for Fucose 
(1-2) Galactose Carbohydrates in Neuronal Growth
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125
Received September 3, 2004
Abstract:
We report a fucose (1-2) galactose-mediated pathway for the modulation of neuronal growth and morphology. Our studies provide strong evidence for the presence of Fuc(1-2)Gal glycoproteins and lectin receptors in hippocampal neurons. Additionally, we show that manipulation of Fuc(1-2)Gal-associated proteins using small-molecule and lectin probes induces dramatic changes in neuronal morphology. These findings may provide a novel pathway to stimulate neuronal growth and regeneration.
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