Dendrimer-like PEO Glycopolymers Exhibit Anti-Inflammatory Properties

J. Am. Chem. Soc., 127 (29), 10132 -10133, 2005. 10.1021/ja0511974 S0002-7863(05)01197-2
Web Release Date: June 30, 2005

Dendrimer-like PEO Glycopolymers Exhibit Anti-Inflammatory Properties

Shyam M. Rele,* Wanxing Cui, Lianchun Wang, Sijian Hou, Ginger Barr-Zarse, Daniel Tatton, Yves Gnanou, Jeffrey D. Esko, and Elliot L. Chaikof*

Departments of Surgery and Biomedical Engineering, Emory University, and School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30322

echaiko@emory.edu; smrele@emory.edu

Received February 24, 2005

Abstract:

A new class of high molecular weight polysulfated PEO dendrimer-like glycopolymer has been synthesized by a combination of arm-first and core-first methodologies followed by trichloroacetimidate glycosidation as a facile bioconjugation strategy. An L-selectin antagonist was identified that exhibits 10³-fold greater activity than other multivalent sLe^x glycopolymers and 20-50 times greater potency than other linear heparinoids. A significant reduction in inflammatory cell recruitment was observed in vivo.

Download the full text: PDF | HTML