Web Release Date: March 22,
New Helical Foldamers: Heterogeneous Backbones with 1:2 and 2:1
:
-Amino Acid Residue Patterns
Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706
Received January 14, 2006
Abstract:
Foldamers, oligomers with strong folding propensities, are subjects of growing interest because such compounds offer unique scaffolds for the development of molecular function. We report two new foldamer classes, oligopeptides with regular 1:2 or 2:1 patterns of - and -amino acid residues. Two distinct helical conformations are detected via 2D NMR in methanol for each backbone. One of the helices for each backbone is characterized via X-ray crystallography.
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