Web Release Date: May 18,
High-Resolution NMR Spectroscopy of a GPCR in Aligned Bicelles
and
Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0307, ProSpect Pharma Inc., 9108A Guilford Road, Columbia, Maryland 21046, and m-phasys GmbH, Vor dem Kreuzberg 17, Tübingen 72070, Germany
Received February 8, 2006
Abstract:
Solid-state NMR spectra with single-site resolution of CXCR1, a G protein-coupled receptor (GPCR), were obtained in magnetically aligned phospholipid bicelles. These results demonstrate that GPCRs in phospholipid bilayers are suitable samples for structure determination by solid-state NMR. The spectra also enable studies of drug-receptor interactions.
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