J. Am. Chem. Soc., 128 (41), 13368 -13369, 2006. 10.1021/ja065708d S0002-7863(06)05708-8
Web Release Date: September 21, 2006

Copyright © 2006 American Chemical Society

Highly Enantioselective Transfer Hydrogenation of ,-Unsaturated Ketones

Nolwenn J. A. Martin and Benjamin List*

Max-Planck-Institut für Kohlenforschung, D-45470 Mülheim an der Ruhr, Germany

list@mpi-muelheim.mpg.de

Received August 7, 2006

Abstract:

We describe an efficient and highly enantioselective conjugate transfer hydrogenation of ,-unsaturated ketones that is catalyzed by a salt made from tert-butyl valinate and a recently introduced powerful chiral phosphoric acid catalyst (TRIP).


Download the full text: PDF | HTML