Web Release Date: December 29,
Azidoproline Containing Helices: Stabilization of the Polyproline II Structure by a Functionalizable Group
Department of Chemistry, University of Basel, St. Johanns-Ring 19, CH-4056 Basel, Switzerland
Received October 5, 2006
Abstract:
The conformation and functionalizability of 4-azidoproline containing polyprolines was studied. The conformational analyses demonstrate that the PPII helix is stabilized by (4R)Azp and destabilized by (4S)Azp. Functionalization of Azp containing polyprolines was accomplished efficiently in a differential fashion by "click chemistry", rendering Azp containing polyprolines attractive molecular scaffolds.
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