Web Release Date: January 19,
High-Resolution Structure of a 
-Peptide Bundle
and
Departments of Chemistry and Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520-8107
Received December 4, 2006
Abstract:
We recently reported that -peptides can form discrete hetero-oligomers in aqueous solution. Here we describe the structure of such an oligomer as determined by X-ray crystallography. The structure of Zwit-1F reveals a homo-octamer of two cupped "hands" composed of both parallel and antiparallel 314-helices. The core of the assembly is composed entirely of solvent-excluded 3-homoleucine residues. The Zwit-1F assembly shares many of the physical characteristics of natural proteins.
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