Gold Catalysts Open a New General Chemoselective Route to Synthesize Oximes by Hydrogenation of,-Unsaturated Nitrocompounds with H2

J. Am. Chem. Soc., 129 (20), 6358 -6359, 2007. 10.1021/ja0704131 S0002-7863(07)00413-1
Web Release Date: April 12, 2007

Gold Catalysts Open a New General Chemoselective Route to Synthesize Oximes by Hydrogenation of ,-Unsaturated Nitrocompounds with H₂

Avelino Corma,* Pedro Serna, and Hermenegildo García

Instituto de Tecnología Química, UPV-CSIC, Av. los Naranjos, s/n, Valencia, Spain

acorma@itq.upv.es

Received January 19, 2007

Abstract:

The unprecedented chemoselective reduction of ,-unsaturated nitroalkenes to oximes using hydrogen has been achieved with gold nanoparticles supported on TiO₂. In contrast to the excellent catalytic performance of gold, related palladium and platinum catalysts are unselective, leading to the reduction of C=C double bond as well as the reduction of the NO₂ to NH₂. The selectivity of Au/TiO₂ for the formation of oximes opens the way for the general use of the Henry reaction in organic synthesis.

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