Peptide Ligation Catalyzed by Functionalized Gold Nanoparticles

J. Am. Chem. Soc., 129 (21), 6676 -6677, 2007. 10.1021/ja070301+ S0002-7863(07)00301-0
Web Release Date: May 9, 2007

Peptide Ligation Catalyzed by Functionalized Gold Nanoparticles

Yannick Fillon, Ayush Verma, Partha Ghosh, Dawn Ernenwein, Vincent M. Rotello,* and Jean Chmielewski*

Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, and Department of Chemistry, University of Massachusetts, Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003

chml@purdue.edu

Received January 15, 2007

Abstract:

Trimethylammonium functionalized gold nanoparticles are demonstrated as templates for the assembly of peptide fragments and their subsequently promoted ligation. This system displays the use of organically tailored nanoparticles as effective supramolecular reagents for catalyzing bond-forming reactions and may also serve as a model for prebiotic conditions where charged surfaces may have promoted the polymerization of the early biopolymers.

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