J. Am. Chem. Soc., 129 (34), 10304 -10305, 2007. 10.1021/ja072410u S0002-7863(07)02410-9
Web Release Date: August 4, 2007

Copyright © 2007 American Chemical Society

Spatially Addressable Multiprotein Nanoarrays Templated by Aptamer-Tagged DNA Nanoarchitectures

Rahul Chhabra, Jaswinder Sharma, Yonggang Ke, Yan Liu, Sherri Rinker, Stuart Lindsay, and Hao Yan*

Department of Chemistry and Biochemistry and The Biodesign Institute, Arizona State University, Tempe, Arizona 85287

hao.yan@asu.edu

Received April 5, 2007

Abstract:

Here we generalize a highly programmable strategy to self-assemble multiprotein nanoarrays with deterministic positional addressability. These protein nanoarrays were templated by aptamer-tagged DNA nanoarchitectures. Arrays of proteins with precisely controlled positions and interprotein spacings offer great potential in proteomics, tissue engineering, and medical diagnostics.

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