J. Am. Chem. Soc., 129 (38), 11688 -11689, 2007. 10.1021/ja074698t S0002-7863(07)04698-7
Web Release Date: September 6, 2007

Copyright © 2007 American Chemical Society

Catalytic Asymmetric Diamination of Conjugated Dienes and Triene

Haifeng Du, Weicheng Yuan, Baoguo Zhao, and Yian Shi*

Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523

yian@lamar.colostate.edu

Received June 26, 2007

Abstract:

This paper describes a catalytic asymmetric diamination process using di-tert-butyldiaziridinone as nitrogen source with catalyst generated from Pd2(dba)3 and chiral phosphorus amidite ligand. A wide variety of conjugated dienes and triene can be effectively diaminated in good yields with high regio-, diastereo-, and enantioselectivities.

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