Web Release Date: November 13,
Synthetic Hydrogenases: Incorporation of an Iron Carbonyl Thiolate into a Designed Peptide
and
Department of Biochemistry and Biophysics, Johnson Research Foundation, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, and Department of Chemistry and Biochemistry and School of Earth and Space Exploration, Arizona State University, Tempe, Arizona 85287
Received July 10, 2007
Abstract:
[FeFe] hydrogenases catalyze reversible hydrogen oxidation at an unusual organometallic active site. Neither enzymatic studies nor synthesis of small molecule models has managed to elucidate the mechanisms of these enzymes. In this paper, we demonstrate the incorporation of an iron carbonyl thiolate mimic of the hydrogenase active site into a de novo artificial peptide, creating the first peptide-based model system for hydrogenases.
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