Web Release Date: December 19,
Biodegradable pH-Sensing Dendritic Nanoprobes for Near-Infrared Fluorescence Lifetime and Intensity Imaging
and
College of Chemistry, University of California, Berkeley, California 94720-1460, and Department of Radiology, School of Medicine, Washington University, St. Louis, Missouri 63110
Received October 24, 2007
Abstract:
The overproduction of acidic byproducts is implicated in the development of numerous diseases, and there is currently great interest in developing contrast agents that can image acidic tissue in vivo. Here we report a biodegradable pH-sensing near-infrared (NIR) nanoprobe capable of providing both fluorescence intensity amplification and lifetime information. The pH-sensing NIR nanoprobe is synthesized, in six high yielding and scalable steps, and functions within the tissue transparency window. Both fluorescence intensity and lifetime provided complementary physiological (low pH) and molecular (released fluorophore binding to albumin) information, respectively.
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