Web Release Date: January 8,
Rhodostreptomycins, Antibiotics Biosynthesized Following Horizontal Gene Transfer from Streptomyces padanus to Rhodococcus fascians
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Department of Biology, Department of Health Sciences and Technology, and Biomaterials Science and Engineering Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, and Department of Chemistry, University of Florida, Gainesville, Florida 32611
Received October 11, 2007
Abstract:
Two antibiotics have been isolated from a strain of Rhodococcus fascians that emerged from a competitive co-culture with Streptomyces padanus. The structures of these compounds were elucidated by detailed analyses by NMR and MS. They belong to the aminoglycoside family of antibiotics, and they are structurally unrelated to the actinomycins that are produced by S. padanus. The compounds have been named rhodostreptomycins A and B, reflecting their rhodococcal origin and streptomycin-like composition. Rhodostreptomycins exhibit antibiotic activity against a range of Gram-positive and Gram-negative bacteria.
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