Web Release Date: January 23,
Self-Duplicating Amplification in a Dynamic Combinatorial Library
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Institut de Science et d'Ingénierie Supramoléculaires, Université Louis Pasteur, 8 Allée Gaspard-Monge, BP 70028, 67083 Strasbourg, and Institut Charles Sadron CNRS - UPR 22, Campus CNRS Cronenbourg, 23 rue du Loess, 67037 Strasbourg Cedex, France
Received November 12, 2007
Abstract:
A dynamic combinatorial library has been designed to produce a set of constituents among which one is able to self-complementarily direct its duplication. The overall molecular distribution in the library evolves along both kinetic and thermodynamic biases, leading to the amplification of the species that reproduces most efficiently and to the depletion of the other competitors.
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