J. Am. Chem. Soc., 130 (12), 3710 -3711, 2008. 10.1021/ja7103125 S0002-7863(71)00312-3
Web Release Date: March 4, 2008

Copyright © 2008 American Chemical Society

Intracellular Spatial Control of Fluorescent Magnetic Nanoparticles

Jinhao Gao, Wei Zhang, Pingbo Huang, Bei Zhang, Xixiang Zhang, and Bing Xu*

Departments of Chemistry, Biology, and Physics, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China

chbingxu@ust.hk

Received November 14, 2007

Abstract:

We report a facile intracellular manipulation of fluorescent magnetic Fe3O4-CdSe nanoparticles using magnetic force. The growth of CdSe quantum dots on Fe3O4 nanoparticles produces Fe3O4-CdSe nanoparticles with two distinct properties, fluorescence and superparamagnetism. After nonspecific surface modification using glutathione (GSH), the hydrophilic Fe3O4-CdSe@GSH nanoparticles can be easily uptaken by an HEK293T cell line. Confocal images indicate that the uptaken nanoparticles can be manipulated using a small magnet. The successful intracellular manipulation of magnetic nanoparticles may offer a new strategy for studying polarized cells.

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