Web Release Date: March 11,
Linear Assemblies of Magnetic Nanoparticles as MRI Contrast Agents
and
School of Chemistry, University of Dublin, Trinity College, Dublin 2, Ireland, National Institute for Cellular Biotechnology, School of Chemical Sciences, Dublin City University, Dublin 9, Ireland, and Institute of Neuroscience, University of Dublin, Trinity College, Dublin 2, Ireland
Received November 9, 2007
Abstract:
Using a one-step procedure we have prepared magnetic fluids comprising of polyelectrolyte stabilized magnetite nanoparticles. These nanocomposites are comprised of linear, chain-like assemblies of magnetic nanoparticles, which can be aligned in parallel arrays by an external magnetic field. We have shown the potential use of these materials as contrast agents by measuring their MR response in live rats. The new magnetic fluids have demonstrated good biocompatibility and potential for in vivo MRI diagnostics.
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