Construction and Validation of an Automated Flow Hydrogenation Instrument for Application in High-Throughput Organic Chemistry

J. Comb. Chem., 10 (1), 88–93, 2008. 10.1021/cc700178a
Web Release Date: December 21, 2007

Construction and Validation of an Automated Flow Hydrogenation Instrument for Application in High-Throughput Organic Chemistry

Bruce Clapham,^* Noel S. Wilson, Melissa J. Michmerhuizen, David P. Blanchard, David M. Dingle, Thomas A. Nemcek, Jeffrey Y. Pan, and Daryl R. Sauer

High-Throughput Organic Synthesis and Automation Engineering, Department of Advanced Technology, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064

Received November 6, 2007

Abstract:

This manuscript details the construction of a fully automated flow hydrogenation apparatus for use in high-throughput organic synthesis. The instrument comprises of a Bohdan robot platform coupled with a ThalesNano H-cube hydrogenator and a series of solvent valves and pumping mechanisms. Using this instrument, we have been able to fully automate a number of key transformations that could not otherwise be conveniently undertaken in a high-throughput manner.

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