Received for review August 12, 2005. Accepted February 14, 2006.

Abstract:

The solubilities of three estrogenic hormones-estrone, 17-estradiol, and 17-ethynylestradiol-and the industrial pollutant bisphenol A were measured in water, dilute acid and alkali (pH 4 and 10, respectively), and aqueous KNO₃ (0.01 mol·L^-1 and 0.1 mol·L^-1). The concentrations of saturated solutions, after equilibration at (25.0 ± 0.5) C with excess solid for 4 days, were determined by HPLC. Six replicate results were obtained for each solute-solvent pair: the coefficient of variation was in most cases < 5 %. The solubilities in pure water with standard deviations were estrone (1.30 ± 0.08) mg·L^-1, 17-estradiol (1.51 ± 0.04) mg·L^-1, 17-ethynylestradiol (9.20 ± 0.09) mg·L^-1, and bisphenol A (300 ± 5) mg·L^-1. The solubility of each of the hormones was unchanged between pH 4 and pH 7 but was greater at pH 10. At pH 7, the hormones became progressively less soluble as the ionic strength increased from 0.0 to 0.1 mol·L^-1. By contrast the solubility of bisphenol A was essentially the same under all of the experimental conditions tested.

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