Web Release Date: February 27,
In Vitro and in Vivo Antitumor Properties of Tetrakis((trishydroxy- methyl)phosphine)gold(I) Chloride
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Departments of Chemistry and Radiology and Missouri University Research Reactor, University of Missouri-Columbia, Columbia, Missouri 65211, Research Service, H. S. Truman Memorial Veterans Hospital, Columbia, Missouri 65211, and Department of Surgery, Aichi-Gakuin University Hospital, Nagoya 464-8561, Japan
Received November 20, 2002
Abstract:
A novel hydrophilic gold compound, tetrakis((trishydroxymethyl)phosphine)gold(I) chloride 1, has been investigated for its antitumor properties. In vitro studies demonstrate that 1 is active against HCT-15, AGS, PC-3, and LNCaP tumor cells. Cell cycle analysis of the HCT-15 cells by flow cytometry revealed elongation of the G1 phase of the cell cycle leading to growth inhibition. Administration of 1 to Balb/C mice inoculated with syngenic meth/A cells demonstrated statistically significant dose-dependent survival time.
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