J. Nat. Prod., 61 (2), 230 -236, 1998. np970434g S0163-3864(97)00434-5
Web Release Date: February 3, 1998

Copyright © 1998 American Chemical Society and American Society of Pharmacognosy

New Sesquiterpene Lactones from Illicium floridanum

Thomas J. Schmidt,* Hildegard M. Schmidt, Eva Müller, Wilfried Peters, Frank R. Fronczek, Aimee Truesdale, and Nikolaus H. Fischer

Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, D-40225 Düsseldorf, Germany, and Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803

Received September 19, 1997

Abstract:

In continuation of our phytochemical investigation of Illicium floridanum Ellis (American star anise, star bush), three new sesquiterpene lactones possessing the anisatin-type carbon skeleton (8,9-seco-prezizaane skeleton), 14-acetoxy-3-oxofloridanolide (1), 13-acetoxy-14-(n-butyryloxy)floridanolide (2), and 3-acetoxy-14-n-butyryloxy-10-deoxyfloridanolide (3), were isolated from fruits of this plant. Their structures were elucidated by 1D and 2D NMR measurements. The molecular structure of 1 was obtained by single crystal X-ray diffraction. The 11,3--lactone structure of the compound previously described as debenzoyldunnianin in our previous communication, on grounds of NMR spectral evidence and X-ray crystallographic analysis is revised to a -lactone closed between C-11 and C-7 (compound 4). The neurotoxic sesquiterpene lactone anisatin (5) and its isomer 2-hydroxyneoanisatin (3-deoxy-2-hydroxyanisatin, 6) were also isolated and identified by spectroscopic means. The presence of the neurotoxin 5 in relatively high amounts in the fruits and leaves confirms and explains early reports on the toxicity of this plant.

Download the full text: PDF | HTML