J. Nat. Prod., 69 (1), 118 -120, 2006. 10.1021/np049600s S0163-3864(04)09600-4
Web Release Date: January 11, 2006

Copyright © 2006 American Chemical Society and American Society of Pharmacognosy

Bacterial Biofilm Inhibitors from Diospyros dendo

Jin-Feng Hu,* Eliane Garo, Matt G. Goering, Mark Pasmore, Hye-Dong Yoo, Tim Esser, Jennifer Sestrich, Peadar A. Cremin, Grayson W. Hough, Peter Perrone, Yin-Shi L. Lee, Ngoc-Tram Le, Mark O'Neil-Johnson, John W. Costerton, and Gary R. Eldridge

Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc., 11199 Sorrento Valley Road, Suite H, San Diego, California 92121, and Center for Biofilm Engineering, Montana State University, 366 EPS Building, Bozeman, Montana 59717

Received December 10, 2004

Abstract:

One new (1) and four known (2-5) ursene triterpenes with potent inhibition of the formation of the bacterial biofilm Pseudomonas aeruginosa PA01 were obtained from Diospyros dendo using a high-throughput natural products chemistry procedure. These compounds were isolated as mass-limited samples. The miniaturization of the structure elucidation and dereplication was performed primarily utilizing a capillary-scale NMR probe.

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