Web Release Date: February 15,
Antibacterial, Partially Acetylated Oligorhamnosides from Cleistopholis patens
Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc., 11199 Sorrento Valley Road, Suite H, San Diego, California 92121, and 1912 Innerbelt Business Center Drive, St. Louis, Missouri 63114
Received October 28, 2005
Abstract:
Three new (1-3) and five known (4-8) partially acetylated oligorhamnoside derivatives were obtained from Cleistopholis
patens via high-throughput natural products chemistry procedures. The rapid structure elucidation and dereplication
were performed primarily utilizing a capillary-scale NMR probe and LR-/HRESIMS spectroscopic methods. Compounds
1, 2, and 6 were found to possess significant in vitro antibacterial activity against the Gram-positive bacteria methicillin-resistant Staphylococcus aureus ATCC 33591 and S. aureus 78-13607A with MICs of 
16 
g/mL. Furthermore, 2 and
6 were found to show significant in vitro antibacterial activity against an expanded panel of Gram-positive pathogens
including either ATCC strains or well-characterized clinical isolates from the global SENTRY Antimicrobial Surveillance
Program.
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