J. Nat. Prod., 70 (6), 968 -973, 2007. 10.1021/np070014j S0163-3864(07)00014-6
Web Release Date: May 31, 2007

Copyright © 2007 American Chemical Society and American Society of Pharmacognosy

Stilbenes from the Orchid Phragmipedium sp.

Eliane Garo,* Jin-Feng Hu, Matt Goering, Grayson Hough, Mark O'Neil-Johnson, and Gary Eldridge

Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences Inc., 1912 Innerbelt Business Center Drive, Saint Louis, Missouri 63114

Received January 9, 2007

Abstract:

Three species of Phragmipedium (Orchidaceae), P. calurum, P. longifolium, and P. hybrid (var. Sorcerer's Apprentice), were analyzed by high-throughput isolation. A total of 12 new (1-4, 6-10, 12, 14, 16) and five known compounds (5, 11, 13, 15, 17) were isolated from these orchids. Compounds 1-8 are stilbenes substituted with one or two 4-hydroxybenzyl moieties. This type of substitution on stilbenes is unusual and has been reported only twice. The structure elucidation was based on spectroscopic analysis.

Download the full text: PDF | HTML