Oxygenated Cembranoids from a Formosan Soft Coral Sinularia gibberosa

J. Nat. Prod., 71 (2), 179–185, 2008. 10.1021/np070356p
Web Release Date: January 17, 2008

Oxygenated Cembranoids from a Formosan Soft Coral Sinularia gibberosa

Atallah F. Ahmed,^†^‡ Zhi-Hong Wen,^† Jui-Hsin Su,^† Ya-Ting Hsieh,^† Yang-Chang Wu,^§ Wan-Ping Hu,^∥ and Jyh-Horng Sheu^*^†^⊥

Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan, Republic of China, Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt, Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China, Faculty of Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China, and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan, Republic of China

Received July 24, 2007

Abstract:

Chemical investigation of a Formosan soft coral, Sinularia gibberosa, has led to the isolation of eight oxygenated cembranoids, 1−8, including seven new compounds, gibberosenes A−G (2−8). None of these compounds were found to be cytotoxic toward a limited panel of cancer cell lines. Compound 1 significantly inhibited the accumulation of the pro-inflammatory COX-2 protein of the LPS-stimulated RAW264.7 macrophage cells.

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