Syntheses of Hemoprotein Models that can be Covalently Attached
onto Electrode Surfaces by Click Chemistry
Richard A. Decréau,James P. Collman,*Ying Yang,Yilong Yan, andNeal K. Devaraj
Department of Chemistry, Stanford University, Stanford, California 94305-5080
jpc@stanford.edu
Received November 14, 2006
Abstract:
Five alkyne-containing hemoprotein models have been synthesized in a convergent manner. Sonogashira
coupling was used to introduce the alkyne functional group on the proximal imidazole before or after
being attached on the porphyrin. One model was immobilized onto a gold electrode surface via copper(I)-catalyzed azide-alkyne cycloaddition (Sharpless click chemistry).
