Web Release Date: November 30,
Preparation and Characterization of Two New Water-Soluble Endohedral Metallofullerenes as Magnetic Resonance Imaging Contrast Agents
and
Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China, and Graduate School of Chinese Academy of Sciences, Beijing, China
Received: July 15, 2007
In Final Form: October 5, 2007
Abstract:
Two new water-soluble Gd-containing endohedral metallofullerenes [ScxGd3-xN@C80Om(OH)n (x = 1, 2; m
12; n 26)] were synthesized in a simple one-step reaction and characterized by Fourier transform (FT)-IR as well as X-ray photoelectron spectroscopy (XPS). Their observed longitudinal relaxivities (R1) for water
protons are 20.7 and 17.6 mM-1 s-1, respectively, which are significantly higher than that of the commercial
magnetic resonance imaging (MRI) contrast agent (Gd-DTPA, 3.2 mM-1 s-1). These results indicate these
trimetallic nitride endohedral fullerenols are potential next-generation high-efficiency MRI contrast agents.
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