Web Release Date: October 16,
Water-Dispersible Polymeric Structure Co-encapsulating a Novel Hexa-peri-hexabenzocoronene Core Containing Chromophore with Enhanced Two-Photon Absorption and Magnetic Nanoparticles for Magnetically Guided Two-Photon Cellular Imaging
Department of Chemistry, Institute for Lasers, Photonics and Biophotonics, State University of New York at Buffalo, Buffalo, New York 14260
Received: June 18, 2007
In Final Form: August 30, 2007
Abstract:
We report the synthesis and characterization of a novel hexa-peri-hexabenzocoronene core (HBCC) containing
chromophore with enhanced two-photon absorption (TPA) compared to that of a corresponding chromophore
containing a hexaphenylbenzene core. With its planar core, the HBCC chromophore has a strong tendency to
aggregate by 
-stacking when entrapped into a biodegradable polymer, diacylphospholipid-polyethyleneglycol
(PE-PEG). Both of these otherwise hydrophobic chromophores exhibit strong fluorescence in aqueous polymeric
micellar solutions. The emission spectrum for the HBCC chromophore in water is strongly dependent on the
concentration of the chromophore encapsulated in micelles. On co-entrapping the HBCC chromophore with
magnetic Fe3O4 nanoparticles in the micelles, it was possible to achieve magnetically guided two-photon
cellular imaging with ample bearing on targeted imaging and therapy.
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