Web Release Date: January 29,
Hyperbranched Poly(amidoamine) as the Stabilizer and Reductant To Prepare Colloid Silver Nanoparticles in Situ and Their Antibacterial Activity
and
School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites and School of Life Science & Biotechnology, Key Laboratory of Microbial Metabolism (Ministry of Education), Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, People's Republic of China
Received: July 12, 2007
In Final Form: October 30, 2007
Abstract:
This study provided a facile and green method to prepare stable colloid silver nanoparticles in aqueous solution
by utilizing the amine-terminated hyperbranched poly(amidoamine) (HPAMAM-NH2) as both stabilizer and
reductant. The formation of silver nanoparticles was verified by FTIR, UV-vis, TEM, EDS, and XRD
measurements. Monodispersed colloid silver nanoparticles with small particle sizes were obtained, and the
average particle size could be effectively controlled from ca. 15 to 4 nm by simply adjusting the molar ratio
of N/Ag in feed. The antibacterial activity of the HPAMAM-NH2/Ag nanocomposites was also investigated
against Gram-positive and Gram-negative bacteria. They were able to efficiently inhibit the growth and
multiplication of several bacteria, including Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and
Klebsiella mobilis, and the bacterial inhibition ratio reached up to 95% at a low silver concentration of 2.7
g/mL.
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