J. Proteome Res., 4 (4), 1114 -1122, 2005. 10.1021/pr050066z S1535-3893(05)00066-7
Web Release Date: July 9, 2005

Copyright © 2005 American Chemical Society

Building Integrated Approaches for the Proteomics of Complex, Dynamic Systems: NIH Programs in Technology and Infrastructure Development

Douglas M. Sheeley,* Joseph J. Breen, and Susan E. Old

National Center for Research Resources, National Institute of Allergy and Infectious Diseases, and National Heart Lung and Blood Institute, The National Institutes of Health, Bethesda, Maryland 20892

Received March 15, 2005

Abstract:

Proteomics technology and methods remain inadequate. Technological constraints contribute to an artificially static view of complex biological systems and a barrier between quantitative and interaction studies. Several NIH programs combine proteomics technology development with research on challenging biological problems to drive progress. A new initiative of the NIH Roadmap focuses on characterization of dynamic systems. The success of these programs will be judged by their impact on relevant biological problems.

Keywords: proteomics NIH quantitation cellular dynamics biomarkers differential expression


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