Web Release Date: July 9,
Building Integrated Approaches for the Proteomics of Complex,
Dynamic Systems: NIH Programs in Technology and Infrastructure
Development

and
National Center for Research Resources, National Institute of Allergy and Infectious Diseases, and National Heart Lung and Blood Institute, The National Institutes of Health, Bethesda, Maryland 20892
Received March 15, 2005

Abstract:
Proteomics technology and methods remain inadequate. Technological constraints contribute to an artificially static view of complex biological systems and a barrier between quantitative and interaction studies. Several NIH programs combine proteomics technology development with research on challenging biological problems to drive progress. A new initiative of the NIH Roadmap focuses on characterization of dynamic systems. The success of these programs will be judged by their impact on relevant biological problems.
Keywords: proteomics
NIH
quantitation
cellular dynamics
biomarkers
differential expression
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