Web Release Date: October 26,
Emulsion Macromonomer Cross-Linking. A Preparative Method for Oxidation-Responsive Nanoparticles with a Controlled Network Structure
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School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom, and Micap plc, Pemberton, Wigan WN5 8AA, United Kingdom
Received July 11, 2007
In Final Form: September 6, 2007
Abstract:
We here report on a preparative, template-based method for oxidation-responsive, poly(propylene sulfide) cross-linked nanoparticles. In this study we demonstrate that preformed, narrow polydispersity, and end-functional polysulfides can be dispersed to yield stable emulsions, which can then be converted into stable nanoparticles through photochemically initiated cross-linking. The nanoparticle size is substantially templated on that of the precursor emulsions; the nanoparticles bulk is an elastomeric material with a homogeneous cross-linking density. The nanoparticles show a peculiar, two-stage behavior upon exposure to oxidants, which is likely composed of a first agglomeration phase followed by swelling.
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