Langmuir, 24 (3), 826 -829, 2008. 10.1021/la7028824 S0743-7463(70)02882-2
Web Release Date: January 11, 2008

Not subject to U.S. Copyright. Published 2008 American Chemical Society

Self-Assembled Monolayers of an Oligo(ethylene oxide) Disulfide and Its Corresponding Thiol Assembled from Water: Characterization and Protein Resistance

David J. Vanderah,* Marlon L. Walker, Mark A. Rocco, and Kenneth A. Rubinson

Biochemical Science Division, Chemical Science and Technology Laboratory, National Institute of Standards and Technology (NIST), Gaithersburg, Maryland 20899, Surface and Microanalysis Science Division, NIST, Gaithersburg, Maryland 20899, and Department of Biochemistry and Molecular Biology, Wright State University, Dayton, Ohio 48202 and NIST Center for Neutron Research (NCNR), Gaithersburg, Maryland 20899

Received September 17, 2007

Abstract:

Self-assembled monolayers (SAMs) of the disulfide [S(CH2CH2O)6CH3]2 ([S(EO)6]2) on Au from 95% ethanol and from 100% water are described. Spectroscopic ellipsometry and reflection-absorption infrared spectroscopy indicate that the [S(EO)6]2 films are similar to the disordered films of HS(CH2CH2O)6CH3 ((EO)6) and HS(CH2)3O(CH2CH2O)5CH3 (C3EO5) at their protein adsorption minima. The [S(EO)6]2 SAMs exhibit constant film thickness (d) of 1.2 ± 0.2 nm over long immersion times (up to 20 days) and do not attain the highly ordered, 7/2 helical structure of the (EO)6 and C3EO5 SAMs (d = 2.0 nm). Exposure of these self-limiting [S(EO)6]2 SAMs to bovine serum albumin show high resistance to protein adsorption.

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