Web Release Date: January 30,
Length-Based Encoding of Binary Data in DNA
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Departments of Bioengineering, Computer Science and Engineering, Biochemistry, and Electrical Engineering, and Center for Nanoscale Science and Engineering, University of California, Riverside, California 92521, and Department of Biology, Loyola Marymount University, 1 LMU Drive, Los Angeles, California 90045
Received October 18, 2007
In Final Form: December 18, 2007
Abstract:
We developed a system to encode digital information in DNA polymers based on the partial restriction digest (PRD). Our encoding method relies on the length of the fragments obtained by the PRD rather than the actual content of the nucleotide sequence, thus eliminating the need for expensive sequencing machinery. In this letter, we report on the encoding of 12 bits of data in a DNA fragment of 110 nucleotides and the process of recovering the data.
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