Web Release Date: February 15,
Macroscopic 2D Networks Self-Assembled from Nanometer-Sized Protein/DNA Complexes
and
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, U.K., Centre for Nanoscience, University of Cambridge, J. J. Thomson Avenue, Cambridge CB3 0FF, U.K., and Department of Biotechnology, University of Western Cape, Cape Town 7535, South Africa
Received August 12, 2005
Revised January 20, 2006
Abstract:
We demonstrate the self-assembly of DNA and DNA binding proteins into two-dimensional networks that are then addressable by sending a second protein to a specific recognition site on the DNA network. These networks cover centimeters in area but can be addressed with nanometer precision. This hierarchical self-assembly of specific DNA protein complexes will be the basis for complex positioning of single molecules in two and three dimensions.
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