Web Release Date: November 2,
Mesoporous Silica Particles Induce Size Dependent Effects on Human Dendritic Cells
mme,
and
Clinical Allergy Research Unit, Department of Medicine Solna, L2:04, Karolinska Institutet and University Hospital, Solna, 171 76 Stockholm, Sweden, and Nanotechnology and Functional Materials, Department of Engineering Sciences, The Ångström Laboratory, Uppsala University, Box 534, 751 21 Uppsala, Sweden
Received June 21, 2007
Revised October 11, 2007
Abstract:
The effects of mesoporous silica nano- (270 nm) and microparticles (2.5 
m) with surface areas above 500 m2/g were evaluated on human
monocyte-derived dendritic cells (MDDC). Size- and concentration-dependent effects were seen where the smaller particles and lower
concentrations affected MDDC to a minor degree compared to the larger particles and higher concentrations, both in terms of viability, uptake,
and immune regulatory markers. Our findings support the further development of mesoporous silica particles in drug and vaccine delivery
systems.
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