Web Release Date: November 3,
A Cellular Trojan Horse for Delivery of Therapeutic Nanoparticles into Tumors
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Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, Department of Chemistry, Rice University, Houston, Texas 77005, Department of Electrical and Computer Engineering, Rice University, Houston, Texas 77005, Birck Nanotechnology Center, Purdue University, West Lafayette, Indiana 47907, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, Bindley BioScience Center, Purdue University, West Lafayette, Indiana 47907, and Laboratory for Nanophotonics, Rice University, Houston, Texas 77005
Received August 31, 2007
Revised September 25, 2007
Abstract:
Destruction of hypoxic regions within tumors, virtually inaccessible to cancer therapies, may well prevent malignant progression. The tumor's recruitment of monocytes into these regions may be exploited for nanoparticle-based delivery. Monocytes containing therapeutic nanoparticles could serve as "Trojan Horses" for nanoparticle transport into these tumor regions. Here we report the demonstration of several key steps toward this therapeutic strategy: phagocytosis of Au nanoshells, and photoinduced cell death of monocytes/macrophages as isolates and within tumor spheroids.
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