Prev. Article Next Article Table of Contents

Letter

Nanodisk Codes

Supporting Info

Lidong Qin,^† Matthew J. Banholzer,^† Jill E. Millstone,^† and Chad A. Mirkin*

Department of Chemistry and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113

Nano Lett., 2007, 7 (12), pp 3849–3853

DOI: 10.1021/nl072606s

Publication Date (Web): November 28, 2007

†

These authors contributed equally to this work.

Corresponding author. E-mail address: chadnano@northwestern.edu.

Abstract

We report a new encoding system based upon dispersible arrays of nanodisks prepared by on-wire lithography and functionalized with Raman active chromophores. These nanodisk arrays are encoded both physically (in a “barcode” pattern) and spectroscopically (Raman) along the array. These structures can be used in covert encoding strategies because of their small size or as biological labels with readout by scanning confocal Raman spectroscopy. As proof-of-concept, we demonstrate their utility in DNA detection in a multiplexed format at target concentrations as low as 100 fM.

View: Full Text HTML | Hi-Res PDF