Web Release Date: November 24,
Removal of Reaction Solvent by Extractive Workup: Survey of Water and Solvent Co-extraction in Various Systems
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Chemical Product Research and Development and Analytical Sciences Research and Development, Eli Lilly & Company, Lilly Development Centre S.A., Rue Granbonpré 11, B-1348 Mont-Saint-Guibert, Belgium
Received for review July 31, 2006.
Abstract:
In some chemical processes, extractive workup is used to remove the solvent of reaction in an aqueous layer and to isolate the product in the organic layer. Most of the time some reaction solvent is co-extracted in the organic layer, along with some water. This has a non-negligible impact on subsequent operations (washing, crystallization), and we have thus determined those levels for ten reaction solvents and five extraction solvents in order to help the process chemist in the development of efficient isolation procedures.
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